Structure of PDB 8f8y Chain B Binding Site BS03

Receptor Information
>8f8y Chain B (length=433) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYH
CPNCEKTHGKSTLKKVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLG
YMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTK
QKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLS
WVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEK
TFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIP
SGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNF
ETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALA
EHEDELPEHFKPSQLIKDLAKEIRLSENASKAV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8f8y Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8f8y A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		C8 H31 C34
Binding residue
(residue number reindexed from 1)		C9 H32 C35
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.-
External links
PDB RCSB:8f8y, PDBe:8f8y, PDBj:8f8y
PDBsum8f8y
PubMed36596360
UniProtO75151|PHF2_HUMAN Lysine-specific demethylase PHF2 (Gene Name=PHF2)

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