Structure of PDB 8egx Chain B Binding Site BS03

Receptor Information
>8egx Chain B (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAINSSTGALYT
TSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVV
TFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN
PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQD
INDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDE
GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQ
LLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANG
NISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD
NYGAPPGAAVQARSSVASLVIFVND
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8egx Chain B Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8egx Structure of the planar cell polarity cadherins Fat4 and Dachsous1.
Resolution3.688 Å
Binding residue
(original residue number in PDB)		E261 D312 E314 D348
Binding residue
(residue number reindexed from 1)		E219 D270 E272 D306
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8egx, PDBe:8egx, PDBj:8egx
PDBsum8egx
PubMed36797229
UniProtQ6V0I7|FAT4_HUMAN Protocadherin Fat 4 (Gene Name=FAT4)

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