Structure of PDB 8cmk Chain B Binding Site BS03

Receptor Information
>8cmk Chain B (length=893) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQAVQALYHDPSGKERASFWLGELQRSVEISDQLLQIRQDSCYFAAQTMK
MKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQ
MPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTE
IIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNF
MANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQ
LFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGL
GDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAY
IQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSME
CFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVR
LPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLAEKPLASA
AAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALV
LARLPLDKITECLSELCSVQVMALKKLLSQEPSSDPTVFLDRLAVIFRHT
NPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRC
VGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLL
DMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQV
VIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELI
GQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWL
ENSLKGLPVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLF
Ligand information
Receptor-Ligand Complex Structure
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PDB8cmk Tyrosine mediated nuclear import of CIRBP reveals a flexible NLS recognition by TNPO3
Resolution2.945 Å
Binding residue
(original residue number in PDB)		D723 Q726 I730 Q771
Binding residue
(residue number reindexed from 1)		D701 Q704 I708 Q749
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cmk, PDBe:8cmk, PDBj:8cmk
PDBsum8cmk
PubMed
UniProtQ9Y5L0|TNPO3_HUMAN Transportin-3 (Gene Name=TNPO3)

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