Structure of PDB 8bf5 Chain B Binding Site BS03

Receptor Information
>8bf5 Chain B (length=726) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLFLIKRIPM
KVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVE
NLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDN
TKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKGFM
ITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASLSP
GMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKDEE
TCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAM
ELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRY
TYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIP
EIVLKYNLMDPEYKGRLLHPQNPFVGHLSKMDYDAVSGTHSWRTKRNRSI
LNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLRM
DARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
Receptor-Ligand Complex Structure
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PDB8bf5 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		Y24 Q124 R126 D444 T492 S493 M506 P509 S510
Binding residue
(residue number reindexed from 1)		Y25 Q125 R127 D438 T486 S487 M500 P503 S504
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bf5, PDBe:8bf5, PDBj:8bf5
PDBsum8bf5
PubMed36596301
UniProtQ5V8Y6

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