Structure of PDB 8bek Chain B Binding Site BS03

Receptor Information
>8bek Chain B (length=732) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTHFQIGKKKQRLNKRSYL
IRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQ
SGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMF
LAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQV
PAEMLANIDLKYFNKSTREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTV
LGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYR
TCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGIN
ESADMSVGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQI
QTRRAFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDE
DYQGRLCNPMNPFVSHKEIDSVNNAVVMPSMEYDAVATTHSWIPKRNRSI
LNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARI
DARIDFESGRIKKEEFAEIMKICSTIEELRRQ
Ligand information
Receptor-Ligand Complex Structure
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PDB8bek Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		H32 T34 M356 R365
Binding residue
(residue number reindexed from 1)		H32 T34 M338 R347
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bek, PDBe:8bek, PDBj:8bek
PDBsum8bek
PubMed36596301
UniProtM9TLW3

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