Structure of PDB 8b7e Chain B Binding Site BS03

Receptor Information
>8b7e Chain B (length=1122) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVG
WLTNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDES
RVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSN
QLFEARKLLRPILQDNANNNVQRNIYNVVDAKHLIEDIREYDVPYHVRVS
IDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSA
VDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNEND
EVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGF
APDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIEL
DPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNP
DETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYV
GGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSV
DKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRL
QPDSIKAERDCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNK
FSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQ
RENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIV
LYDSLQLAHKVILVSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARAL
VERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRV
HQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKG
IKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEG
CYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKS
TSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSA
DIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAAL
QGVSNPVPRVEHPDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8b7e A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		S1032 L1035 M1036
Binding residue
(residue number reindexed from 1)		S968 L971 M972
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b7e, PDBe:8b7e, PDBj:8b7e
PDBsum8b7e
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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