Structure of PDB 8b6k Chain B Binding Site BS03

Receptor Information
>8b6k Chain B (length=1108) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVND
VEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFE
ARKLLRPILQDNANNNVQRNIYNKVDAKHLIEDIREYDVPYHVRVSIDKD
IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVDQI
MMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVAL
LQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDA
EGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL
MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL
RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHV
ESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVT
NFEEIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQPDS
IKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKKKKVLTFDELS
YADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSF
RDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVIL
NSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTD
GIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELK
DPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGS
LAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWL
DVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFL
GEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWT
LDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHP
DWLKRKIA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8b6k A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 R686 N828 S829 Y831 G832 M835 R836 K837 I965 K966 K967 R968 R988 K1063 V1102 T1103 Y1145 K1156
Binding residue
(residue number reindexed from 1)		K452 G453 T454 G455 T456 T494 Y495 G497 G498 R613 N751 S752 Y754 G755 M758 R759 K760 I888 K889 K890 R891 R911 K986 V1025 T1026 Y1068 K1079
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b6k, PDBe:8b6k, PDBj:8b6k
PDBsum8b6k
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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