Structure of PDB 8ack Chain B Binding Site BS03

Receptor Information

>8ack Chain B (length=468) Species: 287 (Pseudomonas aeruginosa)

SICKSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNRAAATPGYQ
ASVDYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQPVTYEWEKD
FTYLSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFPAGSIALIQ
RGTCNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGESYEGGIPV
IFATYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRGNPNNVVMV
GAHLDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFAWWGAEEAG
LVGSTHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDGSDFGLQGP
PGSAAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAFGGLFTGAE
GLKTEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHSDAMAFVTS
WLSLSTKVVDDEIAAAGQ

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8ack Chain B Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ack An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
• Resolution: 1.784 Å
• Binding residue (original residue number in PDB): H296 D308 D369
• Binding residue (residue number reindexed from 1): H253 D265 D326
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0015628 protein secretion by the type II secretion system
• GO:0043952 protein transport by the Sec complex

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:8ack, PDBe:8ack, PDBj:8ack
• PDBsum: 8ack
• PubMed: 37386135
• UniProt: Q9HZQ8|LAP_PSEAE Aminopeptidase (Gene Name=lap)