Structure of PDB 7z1n Chain B Binding Site BS03

Receptor Information
>7z1n Chain B (length=1112) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INTAQDKWHLLPAFLKVKGLVKQHLDSFNYFVDTDLKKIIKANQLILSDV
DPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRLRDMTYSAPIYVDIEYTR
GRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLDPGGYFIV
NGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKN
GKIYLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNL
EESSKLDIYTQQQALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTV
EALDFREKALYIAMMTRRVVMAMYNPKMIDDRDYVGNKRLELAGQLISLL
FEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALLSINVHSNNITSGLNRAI
STGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKSRKVSGPR
ALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLG
VEDITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEF
ISIYSNSHQMAVHIATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDF
DDFLKLGLVEYLDVNEENDSYIALYEKDIVPSMTHLEIEPFTILGAVAGL
IPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKRIDTLLYLMTYPQQPMVK
TKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDRGFGRCET
RRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQ
SGQIYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMS
VSDNDQALIKVLLRQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQG
IVPDIIMNPHGFPSRMTVGKMIELISGKAGVLNGTLEYGTCFGGSKLEDM
SKILVDQGFNYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKMHA
RARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLLERLMISS
DAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNI
APRLRLEDIFQQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7z1n Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7z1n Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		C1095 C1107
Binding residue
(residue number reindexed from 1)		C1058 C1070
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z1n, PDBe:7z1n, PDBj:7z1n
PDBsum7z1n
PubMed36070694
UniProtP22276|RPC2_YEAST DNA-directed RNA polymerase III subunit RPC2 (Gene Name=RET1)

[Back to BioLiP]