Structure of PDB 7y7s Chain B Binding Site BS03

Receptor Information
>7y7s Chain B (length=920) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APVVAARLRNIWPKFPKWLHEAPLAVAWEVTRLFMHCKVDLESLGLKYDP
SWSTARDVTDIWKTLYRLPEKPPNDVFVTAMTGNFESKGSAVVLSAVLDY
NPDNSPTAPLYLVKLKPLMFEQGCRLTRRFGPDRFFEILIPSPTSTSPSV
PPVVSKQPGAVEEVIQWLTMGQHSLVGRQWRAFFAKDAGYRKPLRKPIIK
ERVHFFAETGITFRPDEPVEQRTEFKVSQMLDWLLQLDNNTWQPHLKLFS
RIQLGLSKTYAIMTLEPHQIRHHKTDLLSPSGTGEVMNDGVGRMSRSVAK
RIRDVLGLGDVPSAVQGRFGSAKGMWVIDVDDTGDEDWIETYPSQRKWEC
DFVDKHQRTLEVRSVASELKSAGLNLQLLPVLEDRARDKVKMRQAIGDRL
INDLQRQFSEQKHALNRPVEFRQWVYESYSSRATRVSHGRVPFLAGLPDS
QEETLNFLMNSGFDPKKQKYLQDIAWDLQKRKCDTLKSKLNIRVGRSAYI
YMIADFWGVLEENEVHVGFSSKFRDEEESFTLLSDCDVLVARSPAHFPSD
IQRVRAVFKPELHSLKDVIIFSTKGDVPLAKKLSGGDYDGDMAWVCWDPE
IVDGFVNAEMPLEPDLSRYLKKDKTTFKQLMASHGTGSAAKEQTTYDMIQ
KSFHFALQPNFLGMCTNYKERLCYINNSVSNKPAIILSSLVGNLVDQSKQ
GIVFNEASWAQLRRELLGGALSLPDPMYKSDSWLGRGEPTHIIDYLKFSI
ARPAIDKELEADGAHFWDPDLASYYTFFKEISDKSRSSALLFTTLKNRIG
EVEKEYGRLVKNKDPYPVRVNQVYEKWCAITPKVIRLLELSFLADREMNT
WALLRASTAFKLYYHKSPKFVWQMAGRQLAYIKAQMTSRPGEGAPALMTA
FMYAGLMPDKKFTKQYVARL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7y7s Chain B Residue 1502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7y7s Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D1007 D1009 D1011
Binding residue
(residue number reindexed from 1)		D587 D589 D591
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity

View graph for
Molecular Function
External links
PDB RCSB:7y7s, PDBe:7y7s, PDBj:7y7s
PDBsum7y7s
PubMed36039765
UniProtQ9Y7G6

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