Structure of PDB 7xn7 Chain B Binding Site BS03

Receptor Information
>7xn7 Chain B (length=1164) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYS
SPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKEC
PYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALE
KGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPD
GEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGI
RREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERK
DQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFN
LNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLS
HLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLS
GISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDP
SMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDD
ESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETI
MIAMTPEDLQTNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIPF
PDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAKTQA
MEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRS
YMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRVSGD
DIIIGKTTPIPPDTEELGQRTKYHTKRDASTPLRSTENGIVDQVLLTTNQ
EGLKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVP
DLIINPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNL
LRDNGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARAR
GPVQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAF
RVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELM
AMNIAPRLYTERSG
Ligand information
>7xn7 Chain T (length=53) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgttttaaccgccaaggggattacacccaagacaccaggcacgagacag
aaa
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7xn7 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T456 R497 T791 M792 R1122 R1129 M1133
Binding residue
(residue number reindexed from 1)		T420 R461 T733 M734 R1064 R1071 M1075
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xn7, PDBe:7xn7, PDBj:7xn7
PDBsum7xn7
PubMed35981082
UniProtC4QZQ7

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