Structure of PDB 7xjg Chain B Binding Site BS03

Receptor Information
>7xjg Chain B (length=314) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYGKNPLN
Ligand information
>7xjg Chain H (length=58) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccuuagcgagagguccucuggauguuguuucggcauccugcauugaauc
ugaguuac
.........<<<<...>>>><<<<<<<.....>>>>>>>...........
........
Receptor-Ligand Complex Structure
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PDB7xjg Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		K56 R63 I65 R81 F96 E97 K98 Q100 P164 K231 G236 P237 R238 S239 S249 R257 E258 K261 R264 K266 H268 H269 C272 S286 R298 Y310
Binding residue
(residue number reindexed from 1)		K54 R61 I63 R79 F94 E95 K96 Q98 P162 K229 G234 P235 R236 S237 S247 R255 E256 K259 R262 K264 H266 H267 C270 S284 R296 Y308
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:7xjg, PDBe:7xjg, PDBj:7xjg
PDBsum7xjg
PubMed35982312
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

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