Structure of PDB 7x5m Chain B Binding Site BS03

Receptor Information
>7x5m Chain B (length=170) Species: 4006 (Linum usitatissimum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEYDVFLSFRGPDTRKQFTDFLYHFLCYYKIHTFRDDDELRKGKEIGPNL
LRAIDQSKIYVPIISSGYADSKWCLMELAEIVRRQEEDPRRIILPIFYMV
DPSDVRHQTGCYKKAFRKHANKFDGQTIQNWKDALKKVGDLKGWHIGKDD
EQGAIADKVSADIWSHISKE
Ligand information
Ligand IDACK
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7-6(4(1-16)19-10)20-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyKMYWVDDIPVNLME-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6c1nc(c2c(n1)n(cn2)C3C4C(C(O3)CO)OP(=O)(O4)O)N
OpenEye OEToolkits 2.0.6c1nc(c2c(n1)n(cn2)[C@H]3[C@H]4[C@@H]([C@H](O3)CO)OP(=O)(O4)O)N
CACTVS 3.385Nc1ncnc2n(cnc12)[CH]3O[CH](CO)[CH]4O[P](O)(=O)O[CH]34
CACTVS 3.385Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H]4O[P](O)(=O)O[C@@H]34
FormulaC10 H12 N5 O6 P
Name2',3'- cyclic AMP
ChEMBL
DrugBank
ZINCZINC000001564775
PDB chain7x5m Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x5m TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.
Resolution3.42 Å
Binding residue
(original residue number in PDB)		F64 G69 E97 S129 C132 E135
Binding residue
(residue number reindexed from 1)		F6 G11 E39 S71 C74 E77
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:7x5m, PDBe:7x5m, PDBj:7x5m
PDBsum7x5m
PubMed35597242
UniProtQ9XEH4

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