Structure of PDB 7ux8 Chain B Binding Site BS03

Receptor Information
>7ux8 Chain B (length=361) Species: 202862 (Streptomyces drozdowiczii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVSLVDESLLVGVTDEDRAVRSAHQFYERLIGLWAPAVMEAAHELGVFAA
LAEAPADSGELARRLDCDARAMRVLLDALYAYDVIDRIHDTNGFRYLLSA
EARECLLPGTLFSLVGKFMHDINVAWPAWRNLAEVVRHGARDTSGAESPN
GIAQEDYESLVGGINFWAPPIVTTLSRKLRASGRSGDATASVLDVGCGTG
LYSQLLLREFPRWTATGLDVERIATLANAQALRLGVEERFATRAGDFWRG
GWGTGYDLVLFANIFHLQTPASAVRLMRHAAACLAPDGLVAVVDQIVDAD
REPKTPQDRFALLFAASMTNTGGGDAYTFQEYEEWFTAAGLQRIETLDTP
MHRILLARRAT
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain7ux8 Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ux8 Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		K122 L165 N268 H271 F319 S322
Binding residue
(residue number reindexed from 1)		K117 L160 N263 H266 F314 S317
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7ux8, PDBe:7ux8, PDBj:7ux8
PDBsum7ux8
PubMed36173166
UniProtA0A0D4WTP2

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