Structure of PDB 7u8y Chain B Binding Site BS03

Receptor Information
>7u8y Chain B (length=222) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPP
PVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLA
ILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDS
IAALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKP
QALLQWVDEHARPFSTVKPMYG
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7u8y Chain B Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7u8y TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics
Resolution2.22 Å
Binding residue
(original residue number in PDB)		D18 E20 D200
Binding residue
(residue number reindexed from 1)		D13 E15 D188
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7u8y, PDBe:7u8y, PDBj:7u8y
PDBsum7u8y
PubMed
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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