Structure of PDB 7svb Chain B Binding Site BS03

Receptor Information

>7svb Chain B (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQQTKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLASRKPLVLCGNLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE
LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLL
PALCDSKIRSKALGSDHCPITLYLAL

Ligand information

>7svb Chain E (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggatccgtcgaccgcatcagc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7svb Processing oxidatively damaged bases at DNA strand breaks by APE1.
Resolution	2.24 Å
Binding residue (original residue number in PDB)	G71 R73 A74 K78 K98 E126 G127 Y269 M270
Binding residue (residue number reindexed from 1)	G29 R31 A32 K36 K56 E84 G85 Y227 M228

Enzymatic activity

Enzyme Commision number

3.1.11.2: exodeoxyribonuclease III.
3.1.21.-

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:7svb, PDBe:7svb, PDBj:7svb
PDBsum	7svb
PubMed	36018803
UniProt	P27695\|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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