Structure of PDB 7sl1 Chain B Binding Site BS03

Receptor Information
>7sl1 Chain B (length=813) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDVCPGTAKGKTNCPATVQFVERCWTHSHCQKVCPTICKSHGCTA
EGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRC
VNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTP
CLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAE
LEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYAL
DNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGF
MLFYKEAPYQNVTEFSWTVVDIDPPQRSHPGWLMRGLKPWTQYAIFVKTL
VTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPS
DPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTDSQILKELEESS
FRKTFEDYLHNHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDER
CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVL
YEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGN
GSWTEPTYFYVTD
Ligand information
>7sl1 Chain F (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIEEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
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PDB7sl1 Synergistic activation of the insulin receptor via two distinct sites.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R488 D535 P537 P551 G552 W553 R556
Binding residue
(residue number reindexed from 1)		R485 D523 P525 P530 G531 W532 R535
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sl1, PDBe:7sl1, PDBj:7sl1
PDBsum7sl1
PubMed35361965
UniProtP15208|INSR_MOUSE Insulin receptor (Gene Name=Insr)

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