Structure of PDB 7r3y Chain B Binding Site BS03

Receptor Information
>7r3y Chain B (length=1102) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVND
VEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFE
ARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWLKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
TCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNLTFDELSYADQVIH
IKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEF
KGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYV
MRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILP
KSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIY
ETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGF
ELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHG
LMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKD
KGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLED
LDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKI
AT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r3y Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		P433 Q434 G435 K751 D875 T876 K967 Y969 K982 G983 R988 R989 S1053 Y1059 Q1062
Binding residue
(residue number reindexed from 1)		P374 Q375 G376 K667 D791 T792 K883 Y885 K898 G899 R904 R905 S969 Y975 Q978
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r3y, PDBe:7r3y, PDBj:7r3y
PDBsum7r3y
PubMed35822874
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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