Structure of PDB 7r1f Chain B Binding Site BS03

Receptor Information
>7r1f Chain B (length=728) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAFLIKRI
PMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLV
VENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTG
DNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKG
FMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASL
SPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKD
EETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNF
AMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADY
RYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLH
IPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIMDYDAVSGTHSWRTKRNR
SILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRL
RMDARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
>7r1f Chain M (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB7r1f Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		Y24 Y38 T42 R45 Q124 R126 K237 R238 R239 A240 K308 N310 G411 D444 S493 M506 P509
Binding residue
(residue number reindexed from 1)		Y25 Y39 T43 R46 Q125 R127 K233 R234 R235 A236 K304 N306 G407 D440 S489 M502 P505
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r1f, PDBe:7r1f, PDBj:7r1f
PDBsum7r1f
PubMed36596301
UniProtQ5V8Y6

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