Structure of PDB 7qhm Chain B Binding Site BS03

Receptor Information
>7qhm Chain B (length=534) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSLATVGNNLDSRYTMASGIRRQINKVFPTHWSFMLGEIALYSFIVLLLT
GVYLTLFFDPSITKVIYDGGYLPLNGVEMSRAYATALDISFEVRGGLFIR
QMHHWAALLFVVSMLVHMLRIFFTGAFRRPREANWIIGVVLIILGMAEGF
MGYSLPDDLLSGVGLRIMSAIIVGLPIIGTWMHWLIFGGDFPSDLMLDRF
YIAHVLIIPAILLGLIAAHLALVWYQKHTQFPGAGRTENNVIGIRIMPLF
AVKAVAFGLIVFGFLALLAGVTTINAIWNLGPYNPSQVSAGSQPDVYMLW
TDGAARVMPAWELYLGNYTIPAVFWVAVMLGILVVLLVTYPFIERKFTGD
DAHHNLLQRPRDVPVRTSLGVMALVFYILLTVSGGNDVYAMQFHVSLNAM
TWIGRIGLIVGPAIAYFITYRLCIGLQRSDREVLEHGIETGIIKQMPNGA
FIEVHQPLGPVDDHGHPIPLPYAGAAVPKQMNQLGYAEVETRGGFFGPDP
EDIRAKAKEIEHANHIEEANTLRALNEANIERDK
Ligand information
Ligand IDHEM
InChIInChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
InChIKeyKABFMIBPWCXCRK-RGGAHWMASA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
CACTVS 3.385CC1=C(CCC(O)=O)C2=Cc3n4[Fe]5|6|N2=C1C=c7n5c(=CC8=N|6C(=Cc4c(C)c3CCC(O)=O)C(=C8C=C)C)c(C)c7C=C
ACDLabs 12.01C=1c3c(c(c4C=C5C(=C(C=6C=C7C(=C(C8=CC=2C(=C(C=1N=2[Fe](n34)(N5=6)N78)CCC(=O)O)C)\C=C)C)\C=C)C)C)CCC(=O)O
FormulaC34 H32 Fe N4 O4
NamePROTOPORPHYRIN IX CONTAINING FE;
HEME
ChEMBL
DrugBankDB18267
ZINC
PDB chain7qhm Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7qhm Structural basis for safe and efficient energy conversion in a respiratory supercomplex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		L47 G51 T55 R100 H103 H104 A107 F110 E148 G152 L155 H204 V205 P209
Binding residue
(residue number reindexed from 1)		L47 G51 T55 R100 H103 H104 A107 F110 E148 G152 L155 H204 V205 P209
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.8: quinol--cytochrome-c reductase.
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0022904 respiratory electron transport chain
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qhm, PDBe:7qhm, PDBj:7qhm
PDBsum7qhm
PubMed35087070
UniProtQ79VE9|QCRB_CORGL Cytochrome bc1 complex cytochrome b subunit (Gene Name=qcrB)

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