Structure of PDB 7pks Chain B Binding Site BS03

Receptor Information
>7pks Chain B (length=1112) Species: 9825 (Sus scrofa domesticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAP
PIDLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVD
ITKTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGG
YFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTS
TIWVSMLARQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQ
KEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLD
LAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL
KYSLATGNWGDARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQ
LHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSM
ENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNN
YSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHP
SMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSA
VDRGFFRSVFYRSYKEQESKKQEEVFEKPTRETCQGMRHAIYDKLDDDGL
IAPGVRVSGDDVIIGKTVTLPERRYTKRDCSTFLRTSETGIVDQVMVTLN
QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGIT
PDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKIS
NLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSR
ARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASD
PYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQEL
MSMSIAPRMMSV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pks Structural basis of Integrator-mediated transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R438 T450 L747 R812 R897 R1078 R1085
Binding residue
(residue number reindexed from 1)		R394 T406 L697 R762 R835 R1016 R1023
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pks, PDBe:7pks, PDBj:7pks
PDBsum7pks
PubMed34762484
UniProtA0A0B8RVL1

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