Structure of PDB 7ow8 Chain B Binding Site BS03

Receptor Information
>7ow8 Chain B (length=577) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFSM
SNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLIK
LPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTIL
FIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQI
LPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLM
AALVAVIGYGGMQVSSGELTAGALVAFILYLFQIIMPMGQITTFFTQLQK
SIGATERMIEILAEEEEDTVTGKQIENAHLPIQLDRVSFGYKPDQLILKE
VSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPVDTYS
LESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALN
FIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDAATSSL
DSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGT
HHELMASHGLYRDFAEQQLKMNADLEN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ow8 Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ow8 Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		T381 Q422
Binding residue
(residue number reindexed from 1)		T372 Q413
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0046677 response to antibiotic
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ow8, PDBe:7ow8, PDBj:7ow8
PDBsum7ow8
PubMed35080979
UniProtO06967|BMRA_BACSU Multidrug resistance ABC transporter ATP-binding/permease protein BmrA (Gene Name=bmrA)

[Back to BioLiP]