Structure of PDB 7nut Chain B Binding Site BS03

Receptor Information
>7nut Chain B (length=398) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDC
GGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCP
TLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEA
HLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVS
LGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPA
GRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTL
GQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAAS
LHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7nut Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7nut GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Resolution1.898 Å
Binding residue
(original residue number in PDB)		E143 H211 H232
Binding residue
(residue number reindexed from 1)		E135 H203 H224
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
GO:0047419 N-acetylgalactosamine-6-phosphate deacetylase activity
Biological Process
GO:0006040 amino sugar metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006046 N-acetylglucosamine catabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0019262 N-acetylneuraminate catabolic process
GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nut, PDBe:7nut, PDBj:7nut
PDBsum7nut
PubMed35229715
UniProtQ9Y303|NAGA_HUMAN N-acetylglucosamine-6-phosphate deacetylase (Gene Name=AMDHD2)

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