Structure of PDB 7ntu Chain B Binding Site BS03

Receptor Information
>7ntu Chain B (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB7ntu Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human alpha-thrombin.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y89 P92 R93 Y94 N95 W96 R101 L130 R165 K169 H230 R233 W237 K240 Q244
Binding residue
(residue number reindexed from 1)		Y85 P88 R89 Y90 N91 W92 R98 L130 R162 K166 H234 R237 W241 K244 Q248
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E194 G195 D196 S197 G198
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ntu, PDBe:7ntu, PDBj:7ntu
PDBsum7ntu
PubMed33864869
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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