Structure of PDB 7lo0 Chain B Binding Site BS03

Receptor Information

>7lo0 Chain B (length=153) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESE
EYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTY
RGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHI
NWE

Ligand information

>7lo0 Chain R (length=8) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RRQELLEA

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7lo0 Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Resolution	2.71 Å
Binding residue (original residue number in PDB)	F28 D58 S59 V60 L61 H70 M71 V73
Binding residue (residue number reindexed from 1)	F27 D57 S58 V59 L60 H69 M70 V72

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006325	chromatin organization

	Cellular Component
GO:0005634	nucleus

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7lo0, PDBe:7lo0, PDBj:7lo0
PDBsum	7lo0
PubMed	35136069
UniProt	Q9Y294\|ASF1A_HUMAN Histone chaperone ASF1A (Gene Name=ASF1A)

[Back to BioLiP]