Structure of PDB 7e5a Chain B Binding Site BS03

Receptor Information
>7e5a Chain B (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYL
MNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDV
EKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKA
RNSPDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGS
DQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEF
VQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCI
ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHATSER
EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLK
DIFGPLEEAVKQGIYSKPNLFIQKTEELKAKYYREPRKGIQAEEVLQKYL
KSKESVSHAILQTDQALTETE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7e5a Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7e5a Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S52 T75
Binding residue
(residue number reindexed from 1)		S48 T71
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7e5a, PDBe:7e5a, PDBj:7e5a
PDBsum7e5a
PubMed33876762
UniProtQ96PP8|GBP5_HUMAN Guanylate-binding protein 5 (Gene Name=GBP5)

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