Structure of PDB 6zc9 Chain B Binding Site BS03

Receptor Information
>6zc9 Chain B (length=225) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNV
VGARRSSWRVISSIEQKTKIEMVRAYREKIEKELEAVCQDVLSLLDNYLI
KNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHE
ISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELD
TLNEDSYKDSTLIMQLLRDNLTLWT
Ligand information
Ligand IDCFH
InChIInChI=1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
InChIKeyBYEAHWXPCBROCE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(C(F)(F)F)C(F)(F)F
OpenEye OEToolkits 1.5.0C(C(F)(F)F)(C(F)(F)F)O
ACDLabs 10.04FC(F)(F)C(O)C(F)(F)F
FormulaC3 H2 F6 O
Name1,1,1,3,3,3-hexafluoropropan-2-ol
ChEMBLCHEMBL1231750
DrugBank
ZINCZINC000003860857
PDB chain6zc9 Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zc9 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains.
Resolution1.89896 Å
Binding residue
(original residue number in PDB)		Q9 R12 L13
Binding residue
(residue number reindexed from 1)		Q7 R10 L11
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005080 protein kinase C binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008426 protein kinase C inhibitor activity
GO:0019904 protein domain specific binding
GO:0030971 receptor tyrosine kinase binding
GO:0042802 identical protein binding
GO:0140031 phosphorylation-dependent protein binding
GO:0140311 protein sequestering activity
Biological Process
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0006469 negative regulation of protein kinase activity
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0009966 regulation of signal transduction
GO:0022409 positive regulation of cell-cell adhesion
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0042149 cellular response to glucose starvation
GO:0045664 regulation of neuron differentiation
GO:0048167 regulation of synaptic plasticity
GO:0050870 positive regulation of T cell activation
GO:1904262 negative regulation of TORC1 signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0031982 vesicle
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098793 presynapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zc9, PDBe:6zc9, PDBj:6zc9
PDBsum6zc9
PubMed34294877
UniProtP61981|1433G_HUMAN 14-3-3 protein gamma (Gene Name=YWHAG)

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