Structure of PDB 6xwm Chain B Binding Site BS03

Receptor Information

>6xwm Chain B (length=495) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIE
WAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIE
SWTLGFAIKFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPIL
KPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIR
VFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAI
ITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAV
AIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQP
MIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGV
VFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAV
LLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERR

Ligand information

Ligand ID

InChI

InChI=1S/Na/q+1

InChIKey

FKNQFGJONOIPTF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Na+]

Formula

Name

SODIUM ION

PDB chain

6xwm Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6xwm X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	A22 V23 N27 T254 N286
Binding residue (residue number reindexed from 1)	A10 V11 N15 T242 N274
Annotation score	3

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0035725	sodium ion transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Biological Process

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Cellular Component

External links

PDB	RCSB:6xwm, PDBe:6xwm, PDBj:6xwm
PDBsum	6xwm
PubMed	32081981
UniProt	O67854

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