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Receptor Information

>6waa Chain B (length=702) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTW
EVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHI
ATLLCALFVRHFRTLVKEGHVYVALPPLYRIDLGKEVYYALTEEEKTGVL
EQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLVISDEDEQQ
TTAIMDMLLAKKRSEDRRNWLQEKGAERLALHEFTENAYLNYSMYVIMDR
ALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDVLGKYHPHGD
SACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYA
ELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATD
IPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAEIITSRAEIR
KIYQNGRGSVRMRAVWSKEDGAVVITALPHQVSGAKVLEQIAAQMRNKKL
PMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINL
NMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHILEGL
LVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHLAKLE
EMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDDRRSP
LH

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6waa Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	D421 S422
Binding residue (residue number reindexed from 1)	D22 S23

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

	Cellular Component
GO:0005694	chromosome

PDB	RCSB:6waa, PDBe:6waa, PDBj:6waa
PDBsum	6waa
PubMed	32634310
UniProt	B5XU60

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Structure of PDB 6waa Chain B Binding Site BS03