Structure of PDB 6w3l Chain B Binding Site BS03

Receptor Information
>6w3l Chain B (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE
LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLL
PALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
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PDB6w3l Molecular and structural characterization of disease-associated APE1 polymorphisms.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		G71 R73 A74 K78 K98 G127 Y269 M270
Binding residue
(residue number reindexed from 1)		G29 R31 A32 K36 K56 G85 Y227 M228
Enzymatic activity
Catalytic site (original residue number in PDB) N68 D70 E96 Y171 D210 N212 D283 D308 H309
Catalytic site (residue number reindexed from 1) N26 D28 E54 Y129 D168 N170 D241 D266 H267
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6w3l, PDBe:6w3l, PDBj:6w3l
PDBsum6w3l
PubMed32454397
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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