Structure of PDB 6t18 Chain B Binding Site BS03

Receptor Information

>6t18 Chain B (length=1185) Species: 1245 (Leuconostoc mesenteroides)

SYVADSSGQTYYFDGNGQPLIGLQTIDGNLQYFNQQGVQIKGGFQDVNNK
RIYFAPNTGNAVANTEIINGKLQGRDANGNQVKNAFSKDVAGNTFYFDAN
GVMLTGLQTISGKTYYLDEQGHLRKNYAGTFNNQFMYFDADTGAGKTAIE
YQFDQGLVSQSNENTPHNAAKSYDKSSFENVDGYLTADTWYRPTDILKNG
DTWTASTETDMRPLLMTWWPDKQTQANYLNFMSSKGLGITTTYTAATSQK
TLNDAAFVIQTAIEQQISLKKSTEWLRDAIDSFVKTQANWNKQTEDEAFD
GLQWLQGGFLAYQDDSHRTPNTDSGNNRKLGRQPINIDGSKDTTDGKGSE
FLLANDIDNSNPIVQAEQLNWLHYLMNFGSITGNNDNANFDGIRVDAVDN
VDADLLKIAGDYFKALYGTDKSDANANKHLSILEDWNGKDPQYVNQQGNA
QLTMDYTVTSQFGNSLTHGANNRSNMWYFLDTGYYLNGDLNKKIVDKNRP
NSGTLVNRIANSGDTKVIPNYSFVRAHDYDAQDPIRKAMIDHGIIKNMQD
TFTFDQLAQGMEFYYKDQENPSGFKKYNDYNLPSAYAMLLTNKDTVPRVY
YGDMYLEGGQYMEKGTIYNPVISALLKARIKYVSGGQTMATDSSGKDLKD
GETDLLTSVRFGKGIMTSDQTTTQDNSQDYKNQGIGVIVGNNPDLKLNND
KTITLHMGKAHKNQLYRALVLSNDSGIDVYDSDDKAPTLRTNDNGDLIFH
KTNTFVKQDGTIINYEMKGSLNALISGYLGVWVPVGASDSQDARTVATES
SSSNDGSVFHSNAALDSNVIYEGFSNFQAMPTSPEQSTNVVIATKANLFK
ELGITSFELAPQYRSSGDTNYGGMSFLDSFLNNGYAFTDRYDLGFNKADG
NPNPTKYGTDQDLRNAIEALHKNGMQAIADWVPDQIYALPGKEVVTATRV
DERGNQLKDTDFVNLLYVANTKSSGVDYQAKYGGEFLDKLREEYPSLFKQ
NQVSTGQPIDASTKIKQWSAKYMNGTNILHRGAYYVLKDWATNQYFNIAK
TNEVFLPLQLQNKDAQTGFISDASGVKYYSISGYQAKDTFIEDGNGNWYY
FDKDGYMVRSQQGENPIRTVETSVNTRNGNYYFMPNGVELRKGFGTDNSG
NVYYFDDQGKMVRDKYINDDANNFYHLNVDGTMSR

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 6t18 Chain E Residue 4

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6t18 A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation.
• Resolution: 3.15 Å
• Binding residue (original residue number in PDB): D720 T721 G722
• Binding residue (residue number reindexed from 1): D481 T482 G483
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.1.5: dextransucrase.

Gene Ontology

Molecular Function

• GO:0046527 glucosyltransferase activity

Biological Process

• GO:0009250 glucan biosynthetic process

External links

• PDB: RCSB:6t18, PDBe:6t18, PDBj:6t18
• PDBsum: 6t18
• PubMed: 32409580
• UniProt: Q9RE05