Structure of PDB 6t0n Chain B Binding Site BS03

Receptor Information
>6t0n Chain B (length=749) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRMITQRTIGKK
RVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVELL
ARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITGDNTK
WNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRGYMFE
SKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLSPGMM
MGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGHFKED
IQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVANFSME
LPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKDYRYT
YRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNLHIPE
VCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPAHGPAKSLEYD
AVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYRRP
IGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALKRQG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6t0n Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6t0n A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		G304 D305 D446
Binding residue
(residue number reindexed from 1)		G296 D297 D438
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6t0n, PDBe:6t0n, PDBj:6t0n
PDBsum6t0n
PubMed32304664
UniProtH6QM91

[Back to BioLiP]