Structure of PDB 6s83 Chain B Binding Site BS03

Receptor Information
>6s83 Chain B (length=400) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARNIVVEEIVRTPVEMQQVELVERKGIGHPDSIADGIAEAVSRALCREYI
RRYGVILHHNTDQVEVVGGRAYPRFGGGEVVKPIYILLSGRAVELVDQEL
FPVHEVAIKAAKNYLKNAIRHLDVENHVIIDSRIGQGSVDLVSVFNKARE
NPIPLANDTSFGVGYAPLSETERLVLETEKLLNSEKFKKEYPAVGEDIKV
MGLRRGNEIDLTIAAAIVDSEVATPKEYLEVKDKIKEAVEELAKEITSRK
VNIYVNTADDPERGIYYITVTGTSAEAGDDGSVGRGNRVNGLITPNRHMS
MEAAAGKNPVSHVGKIYNILAMLIAEDIAKTLPVEEVYVRILSQIGKPID
QPLVASIQVIPKPGHSVKEFEKDAYSIADEWLANITKVQKMILEDKISVF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6s83 Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6s83 Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues.
Resolution2.336 Å
Binding residue
(original residue number in PDB)		D63 Q64
Binding residue
(residue number reindexed from 1)		D62 Q63
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6s83, PDBe:6s83, PDBj:6s83
PDBsum6s83
PubMed31962159
UniProtQ8TZW1|METK_PYRFU S-adenosylmethionine synthase (Gene Name=mat)

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