Structure of PDB 6s3h Chain B Binding Site BS03

Receptor Information

>6s3h Chain B (length=423) Species: 751945 (Thermus oshimai JL-2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LSSEQQRAFLAVTQTPHPAHLITGPAGTGKTTLLYALQEFYKGRAVTLAP
TGTAALQARGQTVHSFFRFPARLLRYRHPEDIRPPGPHSPLRKAIEQMEV
LILDEVGMVRVDLLEAMDWALRKTRKRLEEPFGGVKVLLLGDTRQLEPVV
PGGEEALYIARTWGGPFFFQAHVWEEVALRVHRLWESQRQREDPLFAELL
KRLRQGDPQALETLNRAAVRPDGGEEPGTLILTPRRKEADALNLKRLEAL
PGKPLEYQAQVKGEFAETDFPTEAALTLKKGAQVILLRNDPLGEYFNGDL
GWVEDLEAEALAVRLKRNGRRVVIRPFVWEKIVPQVVGTFRQVPVRLAWA
LTVHKAQGLTLDKVHLELGRGLFAHGQLYVALTRVRRLQDLSLSRPIAPT
ELLWRPEVEVFETRIQEGIWQKS

Ligand information

Ligand ID

ALF

InChI

InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4

InChIKey

UYOMQIYKOOHAMK-UHFFFAOYSA-J

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	F[Al-](F)(F)F

Formula

Al F4

Name

TETRAFLUOROALUMINATE ION

PDB chain

6s3h Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6s3h Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.
Resolution	2.06 Å
Binding residue (original residue number in PDB)	A93 G94 K97 E172 Q212 R256 G436 R462
Binding residue (residue number reindexed from 1)	A26 G27 K30 E105 Q145 R189 G358 R384
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003678	DNA helicase activity
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0000723	telomere maintenance
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:6s3h, PDBe:6s3h, PDBj:6s3h
PDBsum	6s3h
PubMed	33784404
UniProt	K7RJ88

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