Structure of PDB 6nbk Chain B Binding Site BS03

Receptor Information

>6nbk Chain B (length=287) Species: 1431339 (Bacillus thuringiensis DB27)

KEISVIGVPMDLGQMRRGVDMGPSAIRYAGVIERIEEIGYDVKDMGDICI
NTKLRNLTQVATVCNELASKVDHIIEEGRFPLVLGGDHSIAIGTLAGVAK
HYKNLGVIWYDAHGDLNTEETSPSGNIHGMSLAASLGYGHSSLVDLYGAY
PKVKKENVVIIGARALDEGEKDFIRNEGIKVFSMHEIDRMGMTAVMEETI
AYLSHTDGVHLSLDLDGLDPHDAPGVGTPVIGGLSYRESHLAMEMLAEAD
IITSAEFVEVNTILDERNRTATTAVALMGSLFGEKLK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 6nbk Chain B Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6nbk Crystal structure of Arginase from Bacillus cereus
• Resolution: 1.91 Å
• Binding residue (original residue number in PDB): D82 E86
• Binding residue (residue number reindexed from 1): D72 E76
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.3.1: arginase.

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0016787 hydrolase activity
• GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000050 urea cycle
• GO:0006525 arginine metabolic process
• GO:0019547 arginine catabolic process to ornithine

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6nbk, PDBe:6nbk, PDBj:6nbk
• PDBsum: 6nbk
• UniProt: W8YSI5