Structure of PDB 6lpi Chain B Binding Site BS03

Receptor Information
>6lpi Chain B (length=539) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STRKRFTGAEFIVHFLEQQGIKIVTGIPGGSILPVYDALSQSTQIRHILA
RHEQGAGFIAQGMARTDGKPAVCMACSGPGATNLVTAIADARLDSIPLIC
ITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVRHIEELPQVMSDAFRI
AQSGRPGPVWIDIPKDVQTAVFEIETQPAMAEKAAAPAFSEESIRDAAAM
INAAKRPVLYLGGGVINAPARVRELAEKAQLPTTMTLMALGMLPKAHPLS
LGMLGMHGVRSTNYILQEADLLIVLGARFDDRAIGKTEQFCPNAKIIHVD
IDRAELGKIKQPHVAIQADVDDVLAQLIPLVEAQPRAEWHQLVADLQRED
PLSHYGLINAVAACVDDNAIITTDVGQHQMWTAQAYPLNRPRQWLTSGGL
GTMGFGLPAAIGAALANPDRKVLCFSGDGSLMMNIQEMATASENQLDVKI
ILMNNEALGLVHQQQSLFYEQGVFAATYPGKINFMQIAAGFGLETCDLPQ
ASLQEIINRPGPALIHVRIDAEEKVYPMVPPGAANTEMV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6lpi Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6lpi Molecular architecture of the acetohydroxyacid synthase holoenzyme.
Resolution2.849 Å
Binding residue
(original residue number in PDB)		D444 N471
Binding residue
(residue number reindexed from 1)		D428 N455
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) I34 G36 G37 S38 I39 E60 C83 F122 Q123 E124 K172 M263 A290 V391 G417 M419 D444 N471 A473 L474 L476 V477 Q480
Catalytic site (residue number reindexed from 1) I27 G29 G30 S31 I32 E53 C76 F115 Q116 E117 K165 M256 A283 V375 G401 M403 D428 N455 A457 L458 L460 V461 Q464
Enzyme Commision number 2.2.1.6: acetolactate synthase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0003984 acetolactate synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005948 acetolactate synthase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lpi, PDBe:6lpi, PDBj:6lpi
PDBsum6lpi
PubMed32538427
UniProtP08142|ILVB_ECOLI Acetolactate synthase isozyme 1 large subunit (Gene Name=ilvB)

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