Structure of PDB 6l2i Chain B Binding Site BS03

Receptor Information

>6l2i Chain B (length=323) Species: 373153 (Streptococcus pneumoniae D39)

VQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGK
SFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGN
AVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYA
VYQDATGNAKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGG
LTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSIS
NTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKL
TAYREQAANLEIEKVGAELRKAM

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6l2i Chain B Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6l2i Crystal Structure of IlvC, a Ketol-Acid Reductoisomerase, from Streptococcus Pneumoniae.
• Resolution: 1.69 Å
• Binding residue (original residue number in PDB): D191 E195
• Binding residue (residue number reindexed from 1): D189 E193
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004455 ketol-acid reductoisomerase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050661 NADP binding

Biological Process

• GO:0008652 amino acid biosynthetic process
• GO:0009082 branched-chain amino acid biosynthetic process
• GO:0009097 isoleucine biosynthetic process
• GO:0009099 L-valine biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:6l2i, PDBe:6l2i, PDBj:6l2i
• PDBsum: 6l2i
• UniProt: Q04M32|ILVC_STRP2 Ketol-acid reductoisomerase (NADP(+)) (Gene Name=ilvC)