Structure of PDB 6j28 Chain B Binding Site BS03

Receptor Information

>6j28 Chain B (length=345) Species: 262724 (Thermus thermophilus HB27)

VNKEALVQVAEEVRRATGLPVGWRDVERTLGALRATRDLWEAVRLSRVPL
RFLVPIWEGLARRGLLRVEEGLDLLAEVPAPRPGEAACPACEGRGLVGER
LPGRAAERFLAWAKERPEAIQDFDQGYVTPESTLARVALAWNWGDLEGKE
VLVLGDDDLTGLAAALTGLPKRVVVLDADPRIVRFLERAAKAEGLPLEAH
VHDLREPLPEAWVHAFHTFFTDPVEGPLGLQAFVGRGLLALEGEGCAGYV
GLTHVEASLAKWADFQRFLLENGAVITELRDGFHVYENWGYIEQMRAWPW
LPVKRRPEKPWYTSALIRLELLRRADLENARVEGDLYDDEESSTT

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 6j28 Chain B Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6j28 The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): C97 C100
• Binding residue (residue number reindexed from 1): C88 C91
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.128: N(4)-bis(aminopropyl)spermidine synthase.

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0046872 metal ion binding

Biological Process

• GO:0006596 polyamine biosynthetic process
• GO:0009058 biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6j28, PDBe:6j28, PDBj:6j28
• PDBsum: 6j28
• PubMed: 31162806
• UniProt: Q72L89