Structure of PDB 6ih7 Chain B Binding Site BS03

Receptor Information
>6ih7 Chain B (length=237) Species: 345073 (Vibrio cholerae O395) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLDFDFTMAFQPIVNCRTKEIFGYEALVRGLNNESAYSVISRVNEDNRYL
FDQMCRVKAIALAAKLGLTSKLSINFLPNAIYVPERCIRTTLEAAKRYQF
PIENIMFEFTEAERVEDVNHIKRIVEYYKSLGFQTAIDDFGSGYSGLNLL
ADFQTNIVKVDMGLIRNIHADQVRQSIMKNCLKLFSDLNIQPLAEGVESH
AEFAWLKAAGVELMQGYYFAKPGFESLPSVNPEFSEA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ih7 Chain B Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ih7 Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		D158 D159 E215
Binding residue
(residue number reindexed from 1)		D138 D139 E195
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.52: cyclic-guanylate-specific phosphodiesterase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6ih7, PDBe:6ih7, PDBj:6ih7
PDBsum6ih7
PubMed31647518
UniProtA0A0H3AJ04

[Back to BioLiP]