Structure of PDB 6hpu Chain B Binding Site BS03

Receptor Information
>6hpu Chain B (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRMQLSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVA
TASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQR
LVIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTK
GSQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDE
VTRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRLQELPGKVHRFEA
MDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVV
GFEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAM
SIHKSQGMTLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVR
CDPRVLHFYATLRRGR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6hpu Chain B Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6hpu Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Resolution3.96 Å
Binding residue
(original residue number in PDB)		S235 G559
Binding residue
(residue number reindexed from 1)		S33 G357
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
Biological Process
GO:0000723 telomere maintenance
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6hpu, PDBe:6hpu, PDBj:6hpu
PDBsum6hpu
PubMed30698796
UniProtQ9H611|PIF1_HUMAN ATP-dependent DNA helicase PIF1 (Gene Name=PIF1)

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