Structure of PDB 6hnv Chain B Binding Site BS03

Receptor Information
>6hnv Chain B (length=467) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDPTHLISKRAAGRTSVSDKPPANFKPHEKPLALSYGMPNHGFFPIDSID
VNLVDYPFQKITPQSTVHISRHTTDPKLIDLARGLQYAAVEGHAPLLQFA
RDFIIRTHKPNYDDWNVFITTGASDGLNKAADVFLDDGDVILVEEFTFSP
FLRFSDNAGAKAVPVKINFDNDSDGIDLTQFVDLLENWEKHYPNLPKPKA
LYTIATGQNPTGFTQSLEFRKKIYDLAVKYDFAIIEDDPYGYLTLPKYEK
PNLEIDDYLKNHLTPSYLELDTTGRVLRVETFSKLFAPGLRLGFIVGHKE
VIDAVKNYSDVVNRGASGLTQTIVNNVIQENFKGVDGWLEWILKMRLNYS
YRKDLLLYSIFESQAYKKGYVDVIDPKAGMFVTFKINLPKDVDVLQKMKL
LLWKLISYGILVVPGYNMTVDLEFSKDRSNFFRLCYALANNDEEILESGK
RLTDAVYEFFSNGLEFH
Ligand information
Ligand IDOOG
InChIInChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)
InChIKeyFGSBNBBHOZHUBO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(CC(=O)C(=O)O)CC(=O)O
ACDLabs 12.01O=C(C(=O)O)CCCC(=O)O
CACTVS 3.385OC(=O)CCCC(=O)C(O)=O
FormulaC6 H8 O5
Name2-OXOADIPIC ACID
ChEMBL
DrugBank
ZINCZINC000001532613
PDB chain6hnv Chain B Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6hnv Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Y130 R371
Binding residue
(residue number reindexed from 1)		Y87 R314
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0008793 aromatic-amino-acid transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
GO:0006571 tyrosine biosynthetic process
GO:0008643 carbohydrate transport
GO:0009058 biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009074 aromatic amino acid family catabolic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0019477 L-lysine catabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hnv, PDBe:6hnv, PDBj:6hnv
PDBsum6hnv
PubMed30742897
UniProtA0A1D8PMC5

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