Structure of PDB 6dgd Chain B Binding Site BS03

Receptor Information
>6dgd Chain B (length=701) Species: 573 (Klebsiella pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVAHVALPVPLPRTFDYLLPEGMAVKAGCRVRVPFGKQERIGIVAAVSER
SELPLDELKPVAEALDDEPVFSTTVWRLLMWAAEYYHHPIGDVLFHALPV
MLRQGKPASATPLWYWFATEQGQVVDLNGLKRSRKQQQALAALRQGKIWR
HQVGELEFNEAALQALRGKGLAELACEAPALTDWRSAYSVAGLRLNTEQA
TAVGAIHSAADRFSAWLLAGITGSGKTEVYLSVLENVLAQGRQALVMVPE
IGLTPQTIARFRQRFNAPVEVLHSGLNDSERLSAWLKAKNGEAAIVIGTR
SSLFTPFKDLGVIVIDEEHDSSYKQQEGWRYHARDLAVWRAHSEQIPIIL
GSATPALETLHNVRQGKYRQLTLSKAQQHVLDLKGQPLQAGLSPALISRM
RQHLQADNQVILFLNRRGFAPALLCHDCGWIAECPRCDSYYTLHQAQHHL
RCHHCDSQRPIPRQCPSCGSTHLVPVGIGTEQLEQALAPLFPEVPISRIR
GGARILIGTQMLAKGHHFPDVTLVSLLDVDGALFSADFRSAERFAQLYTQ
VSGRAGRAGKQGEVILQTHHPEHPLLQTLLYKGYDAFAEQALAERQTMQL
PPWTSHVLIRAEDHNNQQAPLFLQQLRNLLQASPLADEKLWVLGPVPALA
PKRGGRWRWQILLQHPSRVRLQHIVSGTLALINTLPEARKVKWVLDVDPI
E
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6dgd Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6dgd Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase.
Resolution2.823 Å
Binding residue
(original residue number in PDB)		C444 C462 C465
Binding residue
(residue number reindexed from 1)		C434 C452 C455
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0032508 DNA duplex unwinding
Cellular Component
GO:1990077 primosome complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6dgd, PDBe:6dgd, PDBj:6dgd
PDBsum6dgd
PubMed30201718
UniProtA0A1W2ITH4

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