Structure of PDB 6be6 Chain B Binding Site BS03

Receptor Information

>6be6 Chain B (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRQ
ISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYV
FTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQN
YGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIM
YARATSGDKLNNNKFSLCSIRQISQVLEKKRNNCFVESGQPICGNGMVEQ
GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAF
KSKSEKCRDDSDCAREGICNGFTALCPASDPKPQFTDCNRHTQVCINGQC
AGSICEKYGLEECTCAKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTI
TLQPGSPCNDFRGYCDVFMRCRLVDADGPLG

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6be6 Chain B Residue 708 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6be6 Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	I459 C460 N462 M464 E466 E469 D472
Binding residue (residue number reindexed from 1)	I242 C243 N245 M247 E249 E252 D255
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.24.81: ADAM10 endopeptidase.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6be6, PDBe:6be6, PDBj:6be6
PDBsum	6be6
PubMed	29224781
UniProt	O14672\|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

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