Structure of PDB 5ywd Chain B Binding Site BS03

Receptor Information
>5ywd Chain B (length=1154) Species: 10036 (Mesocricetus auratus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNY
QRLCVAFDAQARKGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLC
IFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQT
KIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPV
QIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSN
ERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSIS
IFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLL
SSVVRSTVKALVSVQKLSEFLSSAEIREECVQIIGGFFTWTPDGIPTLSN
ITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQK
PWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGER
GINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILEL
LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSERACTK
YLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLC
SLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL
NRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLA
VVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEAR
FQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSL
HRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTE
AESYEGPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKI
GICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSII
LQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII
TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVM
TAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFA
SFVR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5ywd Chain B Residue 2503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ywd Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		S720 Q775
Binding residue
(residue number reindexed from 1)		S422 Q449
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0043531 ADP binding
GO:0044325 transmembrane transporter binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0001508 action potential
GO:0006813 potassium ion transport
GO:0031669 cellular response to nutrient levels
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0046676 negative regulation of insulin secretion
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0061535 glutamate secretion, neurotransmission
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098793 presynapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ywd, PDBe:5ywd, PDBj:5ywd
PDBsum5ywd
PubMed29594720
UniProtA0A1U7R319

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