Structure of PDB 5wn3 Chain B Binding Site BS03

Receptor Information
>5wn3 Chain B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILC
LQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKVS
YGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFR
KFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEL
LQAVPLADSFRHLYPNTPYAYTAWTYMMNARSKNVGWRLDYFLLSHSLLP
ALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
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PDB5wn3 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		G71 R73 A74 K78 K98 E126 G127 Y269 M270
Binding residue
(residue number reindexed from 1)		G28 R30 A31 K35 K55 E83 G84 Y226 M227
Enzymatic activity
Catalytic site (original residue number in PDB) N68 E96 D210 N212 D283 D308 H309
Catalytic site (residue number reindexed from 1) N25 E53 D167 N169 D240 D265 H266
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5wn3, PDBe:5wn3, PDBj:5wn3
PDBsum5wn3
PubMed29374164
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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