Structure of PDB 5w3v Chain B Binding Site BS03

Receptor Information
>5w3v Chain B (length=182) Species: 9545 (Macaca nemestrina) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKK
EDHAEIRFINEIKSMGLDETQDYQVTCYLTWSPCPSCAGELVDFIKAHRH
LNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDH
KEPPSFNPSEKLKELDKNSQAIKRRLERIKSR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5w3v Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5w3v APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.
Resolution2.243 Å
Binding residue
(original residue number in PDB)		H54 C85 C88
Binding residue
(residue number reindexed from 1)		H53 C84 C87
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0016554 cytidine to uridine editing
GO:0045087 innate immune response
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w3v, PDBe:5w3v, PDBj:5w3v
PDBsum5w3v
PubMed29044109
UniProtA0A1B2AH37

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