Structure of PDB 5uan Chain B Binding Site BS03

Receptor Information
>5uan Chain B (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVT
RNRCQYCRLQKCFEVGMSKESVRTAELDDLTEKIRKAHQETFPSLCQLGK
YTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQ
ITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLE
ALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMP
PLIQEMLE
Ligand information
Receptor-Ligand Complex Structure
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PDB5uan The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission.
Resolution3.508 Å
Binding residue
(original residue number in PDB)		E99 G100 F104 R107 R137
Binding residue
(residue number reindexed from 1)		E20 G21 F25 R28 R58
Binding affinityPDBbind-CN: Kd=32nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uan, PDBe:5uan, PDBj:5uan
PDBsum5uan
PubMed29021580
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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