Structure of PDB 5u6m Chain B Binding Site BS03

Receptor Information
>5u6m Chain B (length=445) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLS
GPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDN
PITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQ
LPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQ
ELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSF
CINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEE
EKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALT
FGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIK
EVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS
Ligand information
Ligand IDSAL
InChIInChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
InChIKeyYGSDEFSMJLZEOE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)c1ccccc1O
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)O
CACTVS 3.341OC(=O)c1ccccc1O
FormulaC7 H6 O3
Name2-HYDROXYBENZOIC ACID;
SALICYLIC ACID
ChEMBLCHEMBL424
DrugBankDB00936
ZINCZINC000000001554
PDB chain5u6m Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5u6m Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana.
Resolution2.568 Å
Binding residue
(original residue number in PDB)		H18 F113 Q134 T365
Binding residue
(residue number reindexed from 1)		H15 F110 Q131 T362
Annotation score2
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0052639 salicylic acid glucosyltransferase (ester-forming) activity
GO:0052640 salicylic acid glucosyltransferase (glucoside-forming) activity
GO:0052641 benzoic acid glucosyltransferase activity
GO:0080002 UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
GO:0090704 nicotinate-O-glucosyltransferase activity
Biological Process
GO:0009696 salicylic acid metabolic process
GO:0010030 positive regulation of seed germination
GO:0018874 benzoate metabolic process
GO:0046482 para-aminobenzoic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5u6m, PDBe:5u6m, PDBj:5u6m
PDBsum5u6m
PubMed28425481
UniProtO22822|U74F2_ARATH UDP-glycosyltransferase 74F2 (Gene Name=UGT74F2)

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