Structure of PDB 5s85 Chain B Binding Site BS03

Receptor Information
>5s85 Chain B (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVM
LRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCL
RIVLSIASGLAHLHIEIFGKPAIAHRDLKSKNILVKKNGQCCIADLGLAV
MHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGL
VLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPN
RWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
Ligand information
Ligand IDXK4
InChIInChI=1S/C3H8N2O/c4-3-1-2-6-5-3/h3,5H,1-2,4H2/t3-/m1/s1
InChIKeyIRMAFFLFVPYKOZ-GSVOUGTGSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C1CONC1N
OpenEye OEToolkits 2.0.7C1CON[C@H]1N
CACTVS 3.385N[C@H]1CCON1
ACDLabs 12.01NC1NOCC1
CACTVS 3.385N[CH]1CCON1
FormulaC3 H8 N2 O
Name(3R)-1,2-oxazolidin-3-amine
ChEMBL
DrugBank
ZINC
PDB chain5s85 Chain B Residue 507 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5s85 XChem group deposition
Resolution1.33 Å
Binding residue
(original residue number in PDB)		R401 I404 R485 L486 T487
Binding residue
(residue number reindexed from 1)		R192 I195 R276 L277 T278
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5s85, PDBe:5s85, PDBj:5s85
PDBsum5s85
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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