Structure of PDB 5mb9 Chain B Binding Site BS03

Receptor Information

>5mb9 Chain B (length=491) Species: 759272 (Thermochaetoides thermophila DSM 1495)

ERVVIGITFGNSNSSIAHTVDDKAEVIANEDGDRQIPTILSYVDGDEYYG
QQAKNFLVRNPKNTVAYFRDILGQDFKSVDPTHNHASAHPQEAGDNVVFT
IKDKAEEDAEPSTLTVSEIATRYLRRLVGAASEYLGKKVTSAVITIPTNF
TEKQKAALIAAAAAADLEVLQLISEPAAAVLAYDARPEATISDKIIVVAD
LGGSRSDVTVLASRSGMYTILATVHDYEYHGIALDKVLIDHFSKEFLKKN
PGAKDPRENPRSLAKLRLEAESTKRALSRSTNASFSVESLIDGLDFASTI
NRLRYETIARTVFEGFNRLVESAVKKAGLDPLDVDEVIMSGGTSNTPRIA
ANFRYIFPESTRILAPSTDPSALNPSELQARGAALQASLIQEFETEDIEQ
STHAAVTTMPHVTNAIGVVSVSFVPIIAPETAVPARRTVHVLVKVVEGST
HINVREKVWKIGSTLAEAAVKVEVTINVNTDLTVIVTAREV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5mb9 Chain B Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5mb9 Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): D211 Q390
• Binding residue (residue number reindexed from 1): D200 Q379
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): T19 R80 E186 D211
• Catalytic site (residue number reindexed from 1): T8 R69 E175 D200

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0140662 ATP-dependent protein folding chaperone

Biological Process

• GO:0006457 protein folding

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol

External links

• PDB: RCSB:5mb9, PDBe:5mb9, PDBj:5mb9
• PDBsum: 5mb9
• PubMed: 28067917
• UniProt: G0RZX9